4D Genome

University of Michigan

Our lab focuses on understanding the dynamics of genome organization in human cells, and how these dynamics shape cell fate in differentiation, cellular reprogramming, and cancer. We have a dual approach of generating time series data in-house using human cells and by using mathematics to identify patterns in data and fill in major unknowns.

Another topic we are interested in is emergence of function. Recently we built a highly idealized mathematical foundation that combines genome (within cell) and diffusion (between cell) dynamical forces. The trade-off between these forces gives rise to the emergence of function in a tissue.

Department of Computational Medicine and Bioinformatics

Department of Mathematics